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| Prudential Hong Kong Tennis Open | ||
| Surface: Hard | Date: Oct. 8 - Oct. 14 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Priscilla Hon | Win | 6-2, 6-3 |
| Second Round | Nao Hibino | Win | 6-0, 6-3 |
| Quarterfinals | Qiang Wang | Loss | 2-6, 4-6 |
| China Open | ||
| Surface: Hard | Date: Sep. 29 - Oct. 7 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Aleksandra Krunic | Loss | 6-0, 4-6, 6-7 (4-7) |
| Dongfeng Motor Wuhan Open | ||
| Surface: Hard | Date: Sep. 23 - Sep. 29 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aryna Sabalenka | Loss | 4-6, 6-2, 1-6 |
| US Open | ||
| Surface: Hard | Date: Aug. 27 - Sep. 9 | Seed: 7 |
| Round | Opponent | W / L | Result |
| First Round | Sachia Vickery | Win | 6-3, 1-6, 6-1 |
| Second Round | Tatjana Maria | Win | 6-2, 6-3 |
| Third Round | Qiang Wang | Win | 6-4, 6-4 |
| Fourth Round | Anastasija Sevastova | Loss | 3-6, 6-1, 0-6 |
| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Svetlana Kuznetsova | Win | 7-6 (7-1), 4-6, 6-4 |
| Third Round | Amanda Anisimova | Win | 6-4, 6-4 |
| Quarterfinals | Kiki Bertens | Loss | 4-6, 3-6 |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mihaela Buzarnescu | Win | 6-3, 6-7 (5-7), 4-3 Retired |
| Third Round | Johanna Konta | Win | 6-3, 6-4 |
| Quarterfinals | Elise Mertens | Win | 7-5, 6-3 |
| Semifinals | Sloane Stephens | Loss | 3-6, 3-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Tatjana Maria | Loss | 6-7 (3-7), 6-4, 1-6 |
| Nature Valley Classic | ||
| Surface: Grass | Date: Jun. 18 - Jun. 24 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Donna Vekic | Win | 6-1, 3-6, 6-1 |
| Second Round | Alize Cornet | Win | 6-4, 6-2 |
| Quarterfinals | Mihaela Buzarnescu | Loss | 3-6, 2-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Ajla Tomljanovic | Win | 7-5, 6-3 |
| Second Round | Viktoria Kuzmova | Win | 6-3, 6-4 |
| Third Round | Mihaela Buzarnescu | Loss | 3-6, 5-7 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Petra Martic | Win | 6-1, 6-2 |
| Third Round | Daria Kasatkina | Win | 0-6, 6-3, 6-2 |
| Quarterfinals | Angelique Kerber | Win | 6-4, 6-4 |
| Semifinals | Anett Kontaveit | Win | 6-4, 6-3 |
| Final | Simona Halep | Win | 6-0, 6-4 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Alize Cornet | Win | 6-2, 6-2 |
| Second Round | Carla Suarez Navarro | Loss | 6-2, 6-7 (3-7), 4-6 |
| Porsche Tennis Grand Prix | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marketa Vondrousova | Win | 2-6, 6-1, 3-2 Retired |
| Quarterfinals | Caroline Garcia | Loss | 7-6 (7-4), 4-6, 2-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Naomi Osaka | Win | 6-4, 6-2 |
| Third Round | Daria Gavrilova | Win | 4-6, 6-0, 6-1 |
| Fourth Round | Ashleigh Barty | Win | 7-5, 6-4 |
| Quarterfinals | Jelena Ostapenko | Loss | 6-7 (3-7), 6-7 (5-7) |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Mona Barthel | Win | 6-4, 6-3 |
| Third Round | Carla Suarez Navarro | Loss | 5-7, 3-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 24 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Qiang Wang | Win | 6-1, 5-7, 6-2 |
| Quarterfinals | Naomi Osaka | Win | 6-2, 6-4 |
| Semifinals | Angelique Kerber | Win | 6-3, 6-3 |
| Final | Daria Kasatkina | Win | 6-4, 6-0 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Marketa Vondrousova | Win | 6-2, 6-4 |
| Third Round | Petra Kvitova | Loss | 4-6, 5-7 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 4 |
| Round | Opponent | W / L | Result |
| First Round | Ivana Jorovic | Win | 6-3, 6-2 |
| Second Round | Katerina Siniakova | Win | 4-6, 6-2, 6-1 |
| Third Round | Marta Kostyuk | Win | 6-2, 6-2 |
| Fourth Round | Denisa Allertova | Win | 6-3, 6-0 |
| Quarterfinals | Elise Mertens | Loss | 4-6, 0-6 |
| Brisbane International presented by Suncorp | ||
| Surface: Hard | Date: Dec. 31 - Jan. 7 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Carla Suarez Navarro | Win | 6-2, 6-4 |
| Second Round | Ana Konjuh | Win | 6-3, 6-1 |
| Quarterfinals | Johanna Konta | Win | 1-6, 7-6 (8-6), 3-2 Retired |
| Semifinals | Karolina Pliskova | Win | 7-5, 7-5 |
| Final | Aliaksandra Sasnovich | Win | 6-2, 6-1 |
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