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| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 13 - Aug. 20 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Elena Vesnina | Win | 6-2, 6-4 |
| Third Round | Ashleigh Barty | Win | 6-4, 6-2 |
| Quarterfinals | Karolina Pliskova | Loss | 2-6, 4-6 |
| Rogers Cup presented by National Bank | ||
| Surface: Hard | Date: Aug. 7 - Aug. 13 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Ekaterina Alexandrova | Win | 6-3, 6-0 |
| Third Round | Agnieszka Radwanska | Win | 6-3, 6-1 |
| Quarterfinals | Karolina Pliskova | Win | 7-5, 6-7 (3-7), 6-4 |
| Semifinals | Sloane Stephens | Win | 6-2, 6-3 |
| Final | Elina Svitolina | Loss | 4-6, 0-6 |
| Ericsson Open | ||
| Surface: Clay | Date: Jul. 24 - Jul. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Pauline Parmentier | Win | 6-3, 3-6, 6-2 |
| Second Round | Viktorija Golubic | Win | 6-2, 2-6, 6-4 |
| Quarterfinals | Kateryna Kozlova | Win | 6-3, 6-1 |
| Semifinals | Elise Mertens | Win | 7-5, 4-6, 6-2 |
| Final | Katerina Siniakova | Loss | 3-6, 4-6 |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 3 - Jul. 16 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Timea Babos | Win | 6-4, 4-6, 6-1 |
| Second Round | Tsvetana Pironkova | Win | 6-3, 6-4 |
| Third Round | Anett Kontaveit | Win | 3-6, 7-6 (7-3), 6-2 |
| Fourth Round | Coco Vandeweghe | Loss | 6-7 (4-7), 4-6 |
| AEGON International Eastbourne | ||
| Surface: Grass | Date: Jun. 25 - Jul. 1 | Seed: 6 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Naomi Osaka | Win | 6-2, 7-6 (7-5) |
| Third Round | Elena Vesnina | Win | 6-1, 6-2 |
| Quarterfinals | Simona Halep | Win | 5-7, 6-4, 6-1 |
| Semifinals | Heather Watson | Win | 6-2, 3-6, 7-5 |
| Final | Karolina Pliskova | Loss | 4-6, 4-6 |
| Roland Garros | ||
| Surface: Red Clay | Date: May 28 - Jun. 11 | Seed: 11 |
| Round | Opponent | W / L | Result |
| First Round | Jaimee Fourlis | Win | 6-4, 3-6, 6-2 |
| Second Round | Francoise Abanda | Win | 6-0, 6-0 |
| Third Round | Catherine Bellis | Win | 6-2, 2-6, 6-3 |
| Fourth Round | Svetlana Kuznetsova | Win | 6-1, 4-6, 6-2 |
| Quarterfinals | Jelena Ostapenko | Loss | 6-4, 2-6, 2-6 |
| Internationaux de Strasbourg | ||
| Surface: Clay | Date: May 22 - May 27 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Shelby Rogers | Loss | 6-7 (8-10), 0-1 Retired |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 6 - May 14 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Monica Niculescu | Win | 7-5, 6-7 (3-7), 6-4 |
| Second Round | Carla Suarez Navarro | Loss | 4-6, 6-2, 2-6 |
| J&T Banka Prague Open | ||
| Surface: Clay | Date: May 1 - May 7 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Misaki Doi | Win | 6-0, 7-5 |
| Second Round | Jelena Ostapenko | Loss | 7-5, 3-6, 6-7 (5-7) |
| Volvo Car Open | ||
| Surface: Green Clay | Date: Apr. 3 - Apr. 9 | Seed: 5 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Annika Beck | Win | 7-5, 6-1 |
| Third Round | Anastasia Rodionova | Win | 6-3, 6-3 |
| Quarterfinals | Jelena Ostapenko | Loss | 2-6, 4-6 |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 21 - Apr. 2 | Seed: 12 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Varvara Lepchenko | Win | 6-1, 6-2 |
| Third Round | Sorana Cirstea | Win | 6-4, 6-2 |
| Fourth Round | Garbine Muguruza | Win | 7-6 (7-1), 0-0 Retired |
| Quarterfinals | Lucie Safarova | Win | 6-4, 6-3 |
| Semifinals | Karolina Pliskova | Win | 5-7, 6-1, 6-1 |
| Final | Johanna Konta | Loss | 4-6, 3-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 9 - Mar. 19 | Seed: 13 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Magda Linette | Win | 6-3, 6-0 |
| Third Round | Katerina Siniakova | Win | 6-3, 6-1 |
| Fourth Round | Madison Keys | Win | 6-4, 6-4 |
| Quarterfinals | Kristina Mladenovic | Loss | 6-3, 6-7 (4-7), 2-6 |
| Dubai Duty Free Tennis Championships | ||
| Surface: Hard | Date: Feb. 19 - Feb. 25 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Daria Kasatkina | Win | 6-2, 7-5 |
| Second Round | Viktorija Golubic | Win | 6-4, 6-2 |
| Third Round | Kateryna Bondarenko | Win | 3-6, 6-2, 6-3 |
| Quarterfinals | Catherine Bellis | Win | 6-3, 6-2 |
| Semifinals | Anastasija Sevastova | Win | 6-3, 6-4 |
| Final | Elina Svitolina | Loss | 4-6, 2-6 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 13 - Feb. 18 | Seed: None |
| Round | Opponent | W / L | Result |
| First Round | Kiki Bertens | Win | 6-2, 6-3 |
| Second Round | Agnieszka Radwanska | Win | 7-5, 6-3 |
| Quarterfinals | Lauren Davis | Win | 7-5, 6-1 |
| Semifinals | Monica Puig | Win | 6-1, 6-2 |
| Final | Karolina Pliskova | Loss | 3-6, 4-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 29 | Seed: 17 |
| Round | Opponent | W / L | Result |
| First Round | Arina Rodionova | Win | 6-1, 6-2 |
| Second Round | Donna Vekic | Win | 6-1, 6-3 |
| Third Round | Johanna Konta | Loss | 3-6, 1-6 |
| Apia International Sydney | ||
| Surface: Hard | Date: Jan. 8 - Jan. 14 | Seed: 10 |
| Round | Opponent | W / L | Result |
| First Round | Monica Puig | Win | 6-3, 2-6, 6-4 |
| Second Round | Yulia Putintseva | Win | 6-0, 7-5 |
| Quarterfinals | Barbora Strycova | Loss | 5-7, 7-6 (8-6), 4-6 |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 2 - Jan. 14 | Seed: 3 |
| Round | Opponent | W / L | Result |
| First Round | Nicole Gibbs | Win | 6-1, 6-0 |
| Second Round | Varvara Lepchenko | Win | 6-3, 6-3 |
| Quarterfinals | Julia Goerges | Loss | 6-1, 3-6, 4-6 |
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