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| Western & Southern Womens Open | ||
| Surface: Hard | Date: Aug. 12 - Aug. 19 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Kiki Bertens |
| Coupe Rogers presentee par Banque Nationale | ||
| Surface: Hard | Date: Aug. 6 - Aug. 12 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Aryna Sabalenka | Loss | 7-5, 2-6, 6-7 (4-7) |
| Wimbledon | ||
| Surface: Grass | Date: Jul. 2 - Jul. 15 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Varvara Lepchenko | Win | 6-0, 6-3 |
| Second Round | Ekaterina Makarova | Loss | 4-6, 6-1, 5-7 |
| Nature Valley International | ||
| Surface: Grass | Date: Jun. 24 - Jun. 30 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Camila Giorgi | Win | 6-2, 6-3 |
| Third Round | Johanna Konta | Win | 4-6, 6-1, 6-4 |
| Quarterfinals | Ashleigh Barty | Win | 6-4, 6-3 |
| Semifinals | Angelique Kerber | Win | 2-6, 7-6 (7-4), 6-4 |
| Final | Aryna Sabalenka | Win | 7-5, 7-6 (7-5) |
| Roland Garros | ||
| Surface: Red Clay | Date: May 27 - Jun. 10 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Danielle Collins | Win | 7-6 (7-2), 6-1 |
| Second Round | Georgina Garcia Perez | Win | 6-1, 6-0 |
| Third Round | Pauline Parmentier | Win | 6-0, 6-3 |
| Fourth Round | Daria Kasatkina | Loss | 6-7 (5-7), 3-6 |
| Internazionali BNL d'Italia | ||
| Surface: Red Clay | Date: May 13 - May 20 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Alison Van Uytvanck | Win | 6-1, 6-4 |
| Third Round | Anastasija Sevastova | Win | 6-2, 5-7, 6-3 |
| Quarterfinals | Anett Kontaveit | Loss | 3-6, 1-6 |
| Mutua Madrid Open | ||
| Surface: Red Clay | Date: May 5 - May 13 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Daria Gavrilova | Win | 6-3, 6-1 |
| Second Round | Ashleigh Barty | Win | 6-2, 4-6, 6-4 |
| Third Round | Kiki Bertens | Loss | 2-6, 2-6 |
| TEB BNP Paribas Istanbul Cup | ||
| Surface: Clay | Date: Apr. 23 - Apr. 29 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Ekaterina Alexandrova | Win | 6-2, 6-2 |
| Second Round | Sara Errani | Win | 5-7, 6-3, 6-3 |
| Quarterfinals | Pauline Parmentier | Loss | 6-4, 3-6, 0-0 Retired |
| Miami Open presented by Itau | ||
| Surface: Hard | Date: Mar. 20 - Apr. 1 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Monica Puig | Loss | 6-0, 4-6, 4-6 |
| BNP Paribas Open | ||
| Surface: Hard | Date: Mar. 7 - Mar. 18 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Lara Arruabarrena | Win | 6-4, 6-1 |
| Third Round | Aliaksandra Sasnovich | Win | 6-4, 2-6, 6-3 |
| Fourth Round | Daria Kasatkina | Loss | 4-6, 5-7 |
| Qatar Total Open | ||
| Surface: Hard | Date: Feb. 12 - Feb. 18 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Carina Witthoeft | Win | 6-2, 6-0 |
| Third Round | Monica Niculescu | Win | 7-5, 6-1 |
| Quarterfinals | Angelique Kerber | Win | 7-6 (7-4), 1-6, 6-3 |
| Semifinals | Petra Kvitova | Loss | 6-3, 6-7 (3-7), 5-7 |
| St. Petersburg Ladies Trophy | ||
| Surface: Hard | Date: Jan. 29 - Feb. 4 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Bye | ||
| Second Round | Anastasia Potapova | Win | 6-0, 6-1 |
| Quarterfinals | Daria Kasatkina | Loss | 6-7 (2-7), 3-6 |
| Australian Open | ||
| Surface: Hard | Date: Jan. 15 - Jan. 28 | Seed: 2 |
| Round | Opponent | W / L | Result |
| First Round | Mihaela Buzarnescu | Win | 6-2, 6-3 |
| Second Round | Jana Fett | Win | 3-6, 6-2, 7-5 |
| Third Round | Kiki Bertens | Win | 6-4, 6-3 |
| Fourth Round | Magdalena Rybarikova | Win | 6-3, 6-0 |
| Quarterfinals | Carla Suarez Navarro | Win | 6-0, 6-7 (3-7), 6-2 |
| Semifinals | Elise Mertens | Win | 6-3, 7-6 (7-2) |
| Final | Simona Halep | Win | 7-6 (7-2), 3-6, 6-4 |
| ASB Classic | ||
| Surface: Hard | Date: Jan. 1 - Jan. 13 | Seed: 1 |
| Round | Opponent | W / L | Result |
| First Round | Madison Brengle | Win | 6-3, 6-0 |
| Second Round | Petra Martic | Win | 6-2, 6-2 |
| Quarterfinals | Sofia Kenin | Win | 4-6, 6-2, 6-4 |
| Semifinals | Sachia Vickery | Win | 6-4, 6-4 |
| Final | Julia Goerges | Loss | 4-6, 6-7 (4-7) |
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